What is ALS(Amyotrophic Lateral Sclerosis)?
Amyotrophic lateral sclerosis (ALS) is a neurological ailment that attacks the nervous system and dramatically impairs physical proficiency; it acts progressively to deteriorate nerve endings until they are eventually gone which then ensues weakened muscular capacity.
Also referred to as Lou Gehrig’s disease, ALS displays muscular pain, irritation, and soreness as its most dominant symptom - traditional medications and therapy are available to help reduce weakness and strengthen muscles. The exact cause of nerve cell degradation remains mostly unknown, and unfortunately, scientists have not yet discovered a cure.
Why use CBD for ALS?
Researchers have analyzed the possibility of CBD harnessing the ability to retrogress the growth of ALS and soothe its typical symptoms. Examinations with ALS-infected mice presented scientists with evidence supporting cannabinoids releasing neuroprotective properties that improves muscular rehabilitation and substantially obstructs the progression of ALS; results also hinted at increased survival rates for those affected with ALS. Scientific observations with humans demonstrated cannabinoids relieving hyperalgesia and adjusting muscular spasticity.
According to the research, cannabinoids decreases glutamate excitotoxicity and postsynaptic calcium influx when activating CB1 cannabinoid receptors; this activation of receptors also exerts anti-glutamatergic activity by prohibiting the delivery of glutamate from presynaptic nerve terminal. The stimulation of CB2 receptors showcases anti-inflammatory effects by regulating inflammatory structures such as the microglial activation inhibition which also causes a decrease in microglia-derived neurotoxic mediators. Additionally, the antioxidant properties of CBD become released through receptor-independent mechanisms.
Bob Strider experienced unusual symptoms of ALS in 1998, specifically the increased loss of function in his right arm and problems swallowing. A devoted cannabis enthusiast, he previously used cannabis for many years, which he is convinced has stored the development of his disease poor but continuous. In 2012, Strider began processing his cannabis natural oils, dosing himself with around a gram per day for 60 days. Within ten days of his routine, he regained control of his right arm and could stop using opiates to control his pain.